Prolonged course of acute generalized exanthematous pustulosis with liver involvement due to sensitization to amoxicillin and paracetamol.

© 2009 The Authors. doi: 10.2340/00015555-0616 Journal Compilation © 2009 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, The EuroSCAR group recently assigned paracetamol as “a drug of common use with no significant association” with acute generalized exanthematous pustulosis (AGEP) (1). However, some rare cases of AGEP in association with paracetamol intake have been reported (2–5). We report here the case of a patient for whom we have good evidence (i.e. by skin testing) that AGEP was elicited by a combination of amoxicillin and paracetamol and who showed unusual liver involvement and prolonged course of the disease.